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Plenary lecture I Friday, September 9th(11:00-11:50) - Grand Ballroom A+B+C(3F)
Chairperson : Duk Kyung Kim
Nabil G. Seidah
University of Montreal
Laboratory of Biochemical
Neuroendocrinology Clinical
Research Institute of Montreal, Canada
The Saga of PCSK9, an LDL-C-regulating Enzyme:
From Bench to Bedside
Dr. Nabil G. Seidah is Professor of Medicine (accreditation in molecular biology, and in biochemistry and molecular medicine), Université de Montréal. Prof. Seidah discovered and cloned seven (PC1, PC2, PC4, PC5, PC7, SKI-1 and PCSK9) of the nine known enzymes belonging to the convertase family. During this period, he also greatly contributed to demonstrating that the proteolysis by the proprotein convertases is a wide mechanism that also concerns “non-neuropeptide” proteins such as growth factors, α-integrins, receptors, enzymes, membrane-bound transcription factors, and bacterial and viral proteins. Recently, he showed that point mutations in the PCSK9 gene cause dominant familial hypercholesterolemia, likely because of a gain of function related to the ability of PCSK9 to enhance the degradation of cell surface receptors, such as the low-density lipoprotein receptor. In this Plenary lecture, he will tell us about “The Saga of PCSK9, an LDL-C-regulating Enzyme: From Bench to Bedside”


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Plenary lecture 2 Saturday, September 10th(10:50-11:40) - Grand Ballroom A+B+C(3F)
Chairperson : Kyong Soo Park
Sidney C. Smith
University of North Carolina,
Heart and Vascular Center, USA
ACC/AHA Guidelines for Treatment of Blood
Cholesterol to Reduce CVD Risk:
Concept and Controversy
Dr. Smith is Professor of Medicine at the University of North Carolina. He is a past president of the American Heart Association (AHA) and chaired the American College of Cardiology (ACC)/AHA guideline committee to revise PCI guidelines, served on the guideline committee for the management of acute myocardial infarction (STEMI), and chaired the AHA/ACC Guidelines on Secondary Prevention. Prof. Smith is a past president of the World Heart Federation (WHF) and chaired the Scientific Advisory Board of the WHF. He was Chair of the Executive Committee for the National Heart, Lung and Blood Institute (NHLBI) Integrated Guidelines for the prevention of cardiovascular disease. In this Plenary lecture, he will tell us about “ACC/AHA Guidelines for Treatment of Blood Cholesterol to Reduce CVD Risk: Concept and Controversy”



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